Enantioselective Denitrogenative Annulation of 1 H ‐Tetrazoles with Styrenes Catalyzed by Rhodium
نویسندگان
چکیده
منابع مشابه
Antibody-Catalyzed Enantioselective Robinson Annulation
We report an antibody that is remarkable in that it catalyzes both steps of an important synthetic transformation, the Robinson annulation. The Robinson annulation which accomplishes, in net terms, the conversion of a f c occupies a key role in organic synthesis.1 In most instances, the overall annulation is comprised of an alkylation (or Michael addition) step leading to b followed by a cyclod...
متن کاملFunctionalization of Styrenes by Copper-Catalyzed Borylation/ ortho-Cyanation and Silver-Catalyzed Annulation Processes.
An efficient two-step method for the assembly of indanone derivatives starting from a simple vinyl arene has been developed. The sequence first involves addition of bis(pinacolato)diboron (B2 pin2 ) and N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) to a broad range of styrenes by utilizing IMesCuCl as catalyst. This step simultaneously accomplishes hydroboration of the alkene and ortho cya...
متن کاملEnantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes.
A denitrogenative annulation reaction of 1,2,3-benzotriazin-4(3H)-ones with allenes catalyzed by a nickel-phosphine complex to produce a variety of substituted 3,4-dihydroisoquinolin-1(2H)-ones in a regioselective manner is described. A highly enantioselective version, as well as structural evidence for the mechanistic course of this reaction, is also presented.
متن کاملRhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation.
Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group. This reaction provides a straightforward way for the synthesis of ortho-alkenyl aryl tetrazoles. Various functional groups tolerate the reaction conditions and afford the corresponding products in moderate to excellent yields.
متن کاملRhodium-Catalyzed, Enantioselective Hydroacylation of ortho-Allylbenzaldehydes.
The development of a rhodium catalyst for endo- and enantioselective hydroacylation of ortho-allylbenzaldehydes is reported. A catalyst generated in situ from [Rh(COD)Cl]2, (R)-DTBM-SEGPHOS, and NaBARF promotes the desired hydroacylation reactions and minimizes the formation of byproducts from competitive alkene isomerization and ene/dehydration pathways. These rhodium-catalyzed processes gener...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2018
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201801283